Table 1. Primary information of 7 potentially functional SNPs and associations with NSCLC risk.
| miRNAs | SNP | Allelea | Casesb | Controlsb | MAFc | Adjusted OR (95%CI)d | Pf | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Additive model | Dominant model | Codominant modele | ||||||||
| het | hom | |||||||||
| miR-143/145 | rs3733846 | A/G | 580/597/164 | 839/925/218 | 0.34/0.34 | 1.01 (0.91–1.13) |
0.97 (0.84–1.11) |
0.93 (0.80–1.08) |
1.11 (0.88–1.40) |
0.810 |
| miR-183/96/182 | rs12538588 | G/A | 1229/112/0 | 1818/163/0 | 0.04/0.04 | 0.98 (0.76–1.26) |
0.98 (0.76–1.26) |
— | — | 0.874 |
| miR-21 | rs1292060 | A/G | 435/645/261 | 648/928/397 | 0.44/0.44 | 1.00 (0.90–1.10) |
1.01 (0.87–1.18) |
1.03 (0.87–1.20) |
0.99 (0.81–1.21) |
0.972 |
| miR-30a | rs763354 | G/A | 486/640/210 | 650/965/352 | 0.40/0.42 |
0.88 (0.80–0.98) |
0.85 (0.74–0.99) |
0.88 (0.75–1.03) |
0.78 (0.64–0.97) |
0.017 |
| miR-200b/200a/429 | rs9660710 | C/A | 431/669/240 | 746/930/306 | 0.43/0.39 |
1.17 (1.06–1.30) |
1.26 (1.09–1.46) |
1.23 (1.05–1.44) |
1.34 (1.09–1.65) |
0.002 |
| miR-210 | rs12286521 | A/G | 752/510/79 | 1126/738/118 | 0.25/0.25 | 1.02 (0.91–1.14) |
1.03 (0.90–1.19) |
1.04 (0.90–1.21) |
0.98 (0.72–1.32) |
0.792 |
| miR-451a | rs901975 | G/A | 571/601/169 | 861/873/245 | 0.35/0.34 | 1.03 (0.93–1.14) |
1.04 (0.90–1.20) |
1.04 (0.90–1.21) |
1.04 (0.83–1.30) |
0.627 |
a
Major/minor allele.
b
Major homozygote/heterozygote/minor homozygote in cases and controls.
c
Minor allele frequency among cases/controls.
d
Logistic regression with adjustment for age, gender and smoking.
e
het: heterozygote versus major homozygote; hom: minor homozygote versus major homozygote.
f
P for additive model.
Bold values are statistically significant.