Table 2. Stratification analysis of rs9660710 and rs763354 genotypes associated with NSCLC risk.
| Variables | rs9660710 (CC/CA/AA)a | OR (95% CI)b | Pc | rs763354 (GG/GA/AA)a | OR (95% CI)b | Pc | ||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |||||
| Age (years) | ||||||||
| < 60 | 187/293/109 | 334/397/142 |
1.18 (1.01–1.37) |
1.000 | 210/276/100 | 309/416/147 | 0.99 (0.85–1.15) |
0.040 |
| ≤ 60 | 244/376/131 | 412/533/164 |
1.18 (1.02–1.35) |
276/364/110 | 341/549/205 |
0.80 (0.70–0.92) |
||
| Gender | ||||||||
| Male | 310/477/161 | 504/649/205 |
1.13 (1.00–1.27) |
0.296 | 357/439/149 | 446/677/233 |
0.86 (0.76–0.97) |
0.443 |
| Female | 121/192/79 | 242/281/101 |
1.27 (1.06–1.53) |
129/201/61 | 204/288/119 | 0.94 (0.77–1.13) |
||
| Smoking | ||||||||
| Never | 175/254/93 | 389/469/162 | 1.14 (0.98–1.33) |
0.624 | 186/251/85 | 342/492/175 | 0.95 (0.81–1.11) |
0.256 |
| Ever | 256/415/147 | 357/461/144 |
1.20 (1.05–1.38) |
300/389/125 | 308/473/177 |
0.84 (0.73–0.97) |
||
| Histological types | ||||||||
| Squamous cell carcinoma | 151/231/99 | 746/930/306 |
1.28 (1.10–1.49) |
0.206 | 172/234/73 | 650/965/352 | 0.86 (0.74–1.00) |
0.725 |
| Adenocarcinoma | 280/438/141 | 746/930/306 |
1.13 (1.00–1.27) |
314/406/137 | 650/965/352 |
0.89 (0.79–1.00) |
||
a
Major homozygote/heterozygote/minor homozygote.
b
Adjusted for age, gender and smoking where appropriate in additive model.
c
P values were from heterogeneity test based on χ2-based Q test.
Bold values are statistically significant.