Table 3. Specific breast cancer subtypes associated with the sites of distant metastasis.
| Site of distant metastasis/subtype | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Abdomen/pelvis | ||||||
| HR+/HER2+ vs. HR+/HER2− | 1.594 | 1.053-2.414 | 0.028* | 1.665 | 1.096-2.530 | 0.017* |
| HR−/HER2+ vs. HR+/HER2− | 1.901 | 1.203-3.002 | 0.006* | 1.971 | 1.244-3.124 | 0.004* |
| HR−/HER2− vs. HR+/HER2− | 1.007 | 0.634-1.601 | 0.976 | 0.933 | 0.624-1.581 | 0.977 |
| HR−/HER2+ vs. HR+/HER2+ | 1.192 | 0.731-1.945 | 0.481 | 1.184 | 0.724-1.936 | 0.501 |
| HR−/HER2− vs. HR+/HER2+ | 0.632 | 0.385-1.037 | 0.069 | 0.596 | 0.662-0.984 | 0.043* |
| HR−/HER2+ vs. HR−/HER2− | 1.887 | 1.109-3.209 | 0.019* | 1.964 | 1.147-3.361 | 0.014* |
| Lung/mediastinum | ||||||
| HR+/HER2+ vs. HR+/HER2− | 1.092 | 0.720-1.659 | 0.678 | 1.138 | 0.747-1.733 | 0.548 |
| HR−/HER2+ vs. HR+/HER2− | 1.113 | 0.698-1.775 | 0.653 | 1.150 | 0.719-1.838 | 0.560 |
| HR−/HER2− vs. HR+/HER2− | 2.709 | 1.766-4.154 | < 0.001* | 2.697 | 1.755-4145 | < 0.001* |
| HR−/HER2+ vs. HR+/HER2+ | 1.019 | 0.612-1.696 | 0.943 | 1.010 | 0.606-1.686 | 0.968 |
| HR−/HER2− vs. HR+/HER2+ | 2.479 | 1.543-3.983 | < 0.001* | 2.370 | 1.471-3.820 | < 0.001* |
| HR−/HER2+ vs. HR−/HER2− | 0.411 | 0.245-0.690 | 0.001* | 0.425 | 0.252-0.717 | 0.001* |
| Pleura | ||||||
| HR+/HER2+ vs. HR+/HER2− | 0.997 | 0.520-1.913 | 0.993 | 1.029 | 0.533-1.987 | 0.932 |
| HR−/HER2+ vs. HR+/HER2− | 0.502 | 0.201-1.251 | 0.139 | 0.552 | 0.220-1.387 | 0.206 |
| HR−/HER2− vs. HR+/HER2− | 0.979 | 0.488-1.965 | 0.952 | 0.991 | 0.491-2.000 | 0.981 |
| HR−/HER2+ vs. HR+/HER2+ | 0.503 | 0.191-1.329 | 0.166 | 0.537 | 0.201-1.429 | 0.213 |
| HR−/HER2− vs. HR+/HER2+ | 0.982 | 0.454-2.122 | 0.963 | 0.963 | 0.442-2.101 | 0.925 |
| HR−/HER2+ vs. HR−/HER2− | 0.513 | 0.188-1.396 | 0.191 | 0.557 | 0.203-1.527 | 0.256 |
| Bone | ||||||
| HR+/HER2+ vs. HR+/HER2− | 0.809 | 0.547-1.195 | 0.287 | 0.809 | 0.547-1.195 | 0.287 |
| HR−/HER2+ vs. HR+/HER2− | 0.426 | 0.270-0.671 | < 0.001* | 0.426 | 0.270-0.671 | < 0.001* |
| HR−/HER2− vs. HR+/HER2− | 0.352 | 0.227-0.547 | < 0.001* | 0.352 | 0.227-0.547 | < 0.001* |
| HR−/HER2+ vs. HR+/HER2+ | 0.527 | 0.321-0.864 | 0.011* | 0.527 | 0.321-0.864 | 0.011* |
| HR−/HER2− vs. HR+/HER2+ | 0.435 | 0.269-0.706 | 0.001* | 0.435 | 0.269-0.706 | 0.001* |
| HR−/HER2+ vs. HR−/HER2− | 1.209 | 0.708-2.066 | 0.487 | 1.251 | 0.729-2.147 | 0.417 |
| Brain | ||||||
| HR+/HER2+ vs. HR+/HER2− | 1.443 | 0.759-2.741 | 0.263 | 1.462 | 0.768-2.783 | 0.248 |
| HR−/HER2+ vs. HR+/HER2− | 1.634 | 0.819-3.260 | 0.164 | 1.690 | 0.843-3.388 | 0.140 |
| HR−/HER2− vs. HR+/HER2− | 2.022 | 1.074-3.805 | 0.029* | 2.054 | 1.089-3.874 | 0.026* |
| HR−/HER2+ vs. HR+/HER2+ | 1.132 | 0.549-2.336 | 0.736 | 1.156 | 0.558-2.396 | 0.697 |
| HR−/HER2− vs. HR+/HER2+ | 1.401 | 0.718-2.734 | 0.322 | 1.405 | 0.719-2.747 | 0.320 |
| HR−/HER2+ vs. HR−/HER2− | 0.808 | 0.395-1.653 | 0.559 | 0.833 | 0.404-1.717 | 0.620 |
| Axillary and/or neck lymph nodes | ||||||
| HR+/HER2+ vs. HR+/HER2− | 1.698 | 0.902-3.197 | 0.101 | 1.588 | 0.836-3.016 | 0.158 |
| HR−/HER2+ vs. HR+/HER2− | 1.457 | 0.707-3.004 | 0.308 | 1.420 | 0.680-2.963 | 0.350 |
| HR−/HER2− vs. HR+/HER2− | 1.226 | 0.597-2.518 | 0.579 | 1.262 | 0.611-2.608 | 0.529 |
| HR−/HER2+ vs. HR+/HER2+ | 0.858 | 0.410-1.794 | 0.684 | 0.894 | 0.422-1.892 | 0.770 |
| HR−/HER2− vs. HR+/HER2+ | 0.722 | 0.347-1.504 | 0.384 | 0.795 | 0.378-1.671 | 0.545 |
| HR−/HER2+ vs. HR−/HER2− | 1.188 | 0.527-2.679 | 0.678 | 1.128 | 0.495-2.567 | 0.775 |
| Other distant soft tissue | ||||||
| HR+/HER2+ vs. HR+/HER2− | 1.455 | 0.636-3.330 | 0.374 | 1.410 | 0.613-3.242 | 0.419 |
| HR−/HER2+ vs. HR+/HER2− | 0.910 | 0.317-2.616 | 0.862 | 0.921 | 0.318-2.665 | 0.880 |
| HR−/HER2− vs. HR+/HER2− | 1.614 | 0.688-3.782 | 0.271 | 1.664 | 0.707-3.915 | 0.243 |
| HR−/HER2+ vs. HR+/HER2+ | 0.626 | 0.211-1.852 | 0.397 | 0.654 | 0.220-1.942 | 0.444 |
| HR−/HER2− vs. HR+/HER2+ | 1.109 | 0.456-2.697 | 0.820 | 1.181 | 0.482-2.891 | 0.716 |
| HR−/HER2+ vs. HR−/HER2− | 0.564 | 0.187-1.702 | 0.310 | 0.564 | 0.186-1.712 | 0.312 |
*
Indicates a significant difference at P < 0.05.
HR, hormone receptor; HER2, human epidermal growth factor receptor 2; OR, odds ratio; CI, confidence interval.