Figure 4. Low-dose ICJ possesses potent metastatic inhibitory activity for breast cancer in vivo.

A,B. After surgical removal of primary tumor, the metastatic condition of the animal model described in Figure 3 was monitored by small animal imaging system. The images from 3 representative mice were shown in (A). Images were quantified by measuring the total photon values of metastases (B) and the counting of metastatic sites (C). D. Survival analysis of the ICJ treated tumor-bearing mice. The survival period has been obviously prolonged by ICJ. E. Histological analysis of the metastatic intensity in lungs from the mice mentioned above. The lung tissue samples were randomly selected from 5 mice in different groups.