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. 2016 Jun 23;7(30):48346–48359. doi: 10.18632/oncotarget.10233

Figure 5. Effects of AURKA on FAK, PI3K, Akt activity.

Figure 5

A. Expression of FAK/PI3K/Akt pathway regulatory factors in T-Hep2 and D-Hep2 cells as analyzed by western blotting. These factors were overexpressed in T-Hep2 cells compared with D-Hep2 cells. B. Protein ratio in T-Hep2 and D-Hep2 cells (*P<0.05, **P<0.01). C. Effects of VX680 in T-Hep2 cells at 0, 24 and 48 h on the FAK/PI3K/Akt pathway as analyzed by western blotting. p-FAK (Tyr397), p-PI3K and p-Akt levels in treated T-Hep2 cells were lower than in untreated cells. D. Protein ratio in T-Hep2 cells (**P<0.01). E. Effects of AURKA upregulation in D-Hep2 cells on the FAK/PI3K/Akt pathway as analyzed by western blotting, p-FAK(Tyr397), p-PI3K and p-Akt levels were higher in transfected D-Hep2 cells compared to untransfected cells. F. Protein ratio in D-Hep2 cells (**P<0.01).