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. 2016 Jun 24;7(30):48391–48400. doi: 10.18632/oncotarget.10268

Figure 4. The upregulation of USP2 is p53-dependent.

Figure 4

a. USP2 expression is induced by nutlin3a and PUVA in Mac2a with functional p53, but not in Hut-78 and SeAx cells with impaired p53. USP2 expression was examined in Hut-78, SeAx and Mac2a cells treated with nutlin3a and PUVA as shown in figure 2. The experiment was repeated 3 times. Unpaired T-test was used to calculate P-value, error-bars, SD. b. Knockdown of p53 reduces induction of USP2 expression upon nutlin3a treatment. USP2 expression was checked in MyLa2000 cells with silenced p53 24h after nutlin3a treatment. Values are means of three independent experiments, paired T-test was used to calculate P-value, Error-bars, SEM. c. Hut-78 apoptosis is not increased upon USP2 knockdown after PUVA treatment. The experiment was performed and presented as described in figure 3. Paired T-test was used to calculate P-value, Error-bars, SEM.