Table 4. Prognostic factors evaluated by univariate and multivariate analysis using Cox proportional hazard model (n=134).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI*) | p | HR (95% CI*) | P | |
| Sex (male/female) | 0.646 (0.375-1.111) | 0.114 | ||
| Age (>63/≤63) | 0.979 (0.603-1.589) | 0.930 | ||
| AJCC stage (I/II/IIIA) | 2.191 (1.534-3.130) | 0.000 | 2.091 (1.455-3.005) | 0.000 |
| Pathologic type (SCC/AC/ASC/LCC#) | 1.152 (0.927-1.431) | 0.201 | ||
| Pathologic differentiation (high/median/low) | 0.905 (0.569-1.439) | 0.674 | ||
| Vascular invasion (ngative/positive) | 1.111 (0.507-2.433) | 0.792 | ||
| miRNA-200a expression in cancer cells (low/high) | 0.692 (0.426-1.124) | 0.137 | ||
| miRNA-200a expression in stromal fibroblasts (low/high) | 0.607 (0.373-0.986) | 0.044 | 0.789 (0.473-1.315) | 0.363 |
| HGF expression in cancer cells (low/high) | 1.070 (0.545-2.097) | 0.845 | ||
| HGF expression in stromal fibroblasts (low/high) | 2.364 (1.440-3.882) | 0.001 | 1.892 (1.120-3.195) | 0.017 |
#
SCC/AC/ASC/LCC: squamous carcinoma/adenocarcinoma/adenosquamous carcinoma/large cell carcinoma
*
CI: confidence interval