Table 1. The main pharmacokinetic parameters of NPPA-PTX and PTX after intravenous administration of the NPPAPTX (equimolar with 5 mg/kg PTX) and Taxol (PTX 5 mg/kg) in rats (mean ± S.D., n = 5).

Parameters	Unit	PTX	NPPA-PTX
Cmax	μM	6.2±0.6	6.7±0.8
AUC(0-14)	μM*h	6.0±0.5	18.5±1.5**
AUC0-inf	μM*h	6.6±0.4	40.1±9.8**
t1/2	h	4.6±1.0	24.4±9.6**
MRT(0-14)	h	3.0±0.2	3.9±0.2**
MRT0-inf	h	4.9±0.5	28.6±11.4**

^**p<0.01 vs PTX group