Table 2. Validation of MMP phenotypes and modeling of conserved human disease alleles by CRISPR-Cas9.

The domains, residue changes, conservation, dauer phenotype, and associated statistics for each of the engineered alleles are given. Residue numbering refers to the preproreceptor. Vertical colored bars reflecting different protein domains are consistent throughout tables and figures as defined in Figure 3. Dauer, number of dauer larvae; EL, number of embryonic lethal; Binding, ligand binding; FnIII, fibronectin Type III; Tyr K, tyrosine kinase; C-term, C-terminal.

^aSubstituting residue is found at the corresponding location in a human insulin-like receptor.