Table 3. Phenotypic consequences of human INSR and corresponding C. elegans DAF-2 mutations.

The human INSR residue change (INSR Δ), associated human disorder, worm DAF-2 residue change (DAF-2 Δ), worm allele name (Allele), associated worm phenotype, and class as defined in (Gems et al. 1998; Patel et al. 2008) are shown. Residue numbering refers to the preproreceptor. NC, nonconditional Daf-c; WT, wild-type; ?, unknown; DS, Donohue Syndrome; RMS, Rabson-Mendenhall Syndrome. Colors as described in Figure 3.