Table 1.
Genes encoding regulators of bone growth, collagens, and proteins involved in calcium signaling and homeostasis, retinoid, and Shh pathways, reduced in expression in E14.5 RA-treated lower incisors.
| Symbol | Name | FC log2 | p-value |
|---|---|---|---|
| BONE/OSTEOBLAST GROWTH | |||
| Bmp2 | Bone morphogenetic protein 2 | −0.35 | 1.08 E-02 |
| Bmp3 | Bone morphogenetic protein 3 | −0.33 | 1.93 E-02 |
| Bmp5 | Bone morphogenetic protein 5 | −0.43 | 1.72 E-02 |
| Ostn | Osteocrin | −1.30 | 8,96 E-05 |
| Sp7 | Sp7 transcription factor 7 | −0.80 | 2,62 E-05 |
| Smoc2 | SPARC modular calcium binding 2 | −0.73 | 1,74 E-08 |
| Runx2 | Runt related transcription factor 2 | −0.38 | 2.98 E-02 |
| Runx3 | Runt related transcription factor 3 | −0.62 | 7.01 E-06 |
| Dlx5 | Distal-less homeobox 5 | −0.58 | 1.64 E-03 |
| Dlx3 | Distal-less homeobox 3 | −0.53 | 8.37 E-03 |
| Mef2c | Myocyte enhancer factor 2C | −0.58 | 6.33 E-05 |
| Ltbp2 | Latent transforming growth factor β binding protein 2 | −0.86 | 1.98 E-06 |
| Fgf10 | Fibroblast growth factor 10 | −0.42 | 4.17 E-04 |
| Fam20a | Family with sequence similarity 20A | −0.64 | 2.71 E-04 |
| Tnn | Tenascin N | −1.18 | 2.01 E-10 |
| Sox6 | SRY (sex determining region Y)-box 6 | −0.41 | 1.20 E-02 |
| Tgfb3 | Transforming growth factor β 3 | −0.31 | 1.45 E-04 |
| COLLAGEN | |||
| Col1a1 | Collagen, type I, α 1 | −0.61 | 6.25 E-03 |
| Col1a2 | Collagen, type I, α 2 | −0.43 | 3.62 E-02 |
| Col5a1 | Collagen, type V, α 1 | −0.37 | 1,39 E-04 |
| Col6a3 | Collagen, type VI, α 3 | −0.42 | 8.34 E-05 |
| Col8a1 | Collagen, type VIII, α 1 | −0.79 | 3.74 E-04 |
| Col8a2 | Collagen, type VIII, α 2 | −0.53 | 1.25 E-04 |
| Col12a1 | Collagen, type XII, α 1 | −0.63 | 1.43 E-04 |
| CALCIUM SIGNALING AND HOMEOSTASIS | |||
| Capn3 | Calpain 3 | −1.03 | 1.78 E-03 |
| Otof | Otoferlin | −0.82 | 3.68 E-03 |
| Kcnma1 | Potassium calcium-activated channel Mα 1 | −0.54 | 8.47 E-03 |
| Cacna2d2 | Calcium channel, voltage dependent, α2/δ2 | −0.48 | 2.26 E-03 |
| RETINOID SIGNALING | |||
| Aldh1a1 | Retinaldehyde dehydrogenase 1 | −0.80 | 1.22 E-02 |
| Aldh1a3 | Retinaldehyde dehydrogenase 3 | −0.69 | 2.70 E-03 |
| Rbp2 | Retinol binding protein 2 | −0.86 | 4.68 E-02 |
| Cyp26c1 | Cytochrome P450 26c1 | −0.29 | 3.77 E-01 |
| SHH SIGNALING | |||
| Ihh | Indian hedgehog | −1.40 | 1.84 E-06 |
| Hhip | Hedgehog-interacting protein | −0.65 | 1.64 E-05 |
| Ptch1 | Patched 1 | −0.42 | 3.04 E-02 |
Data are presented as log2 fold changes in RA-treated vs. control samples: for instance, a FC log2 value of −1.00 will correspond to a 50% mRNA level in the RA-treated samples.