Table 2.
Hepatitis E virus seroprevalence in the general population and potential determinants for HEV seropositivity
| Determinants | N | Seroprevalence (%)a | Crude ORb | [95% CI]c | Adjusted ORb,d,e | [95% CI]c |
|---|---|---|---|---|---|---|
| Age (years) | ||||||
| 20–30 | 50 | 10.0 | Ref. | Ref. | ||
| 30–40 | 179 | 15.1 | 1.60 | [0.58–4.39] | 1.49 | [0.54–4.13] |
| 40–50 | 432 | 19.2 | 2.14 | [0.82–5.55] | 2.01 | [0.77–5.26] |
| 50–60 | 661 | 25.1 | 3.02 | [1.18–7.72] | 2.58 | [1.00–6.70] |
| 60–70 | 938 | 37.5 | 5.40 | [2.13–13.73] | 4.22 | [1.63–10.91] |
| > =70 | 162 | 38.3 | 5.58 | [2.10–14.80] | 4.15 | [1.53–11.24] |
| Gender | ||||||
| Female | 1,318 | 25.6 | Ref. | Ref. | ||
| Male | 1,104 | 32.3 | 1.39 | [1.16–1.65] | 1.21 | [1.00–1.47] |
| Educational level | ||||||
| High | 733 | 24.8 | Ref. | Ref. | ||
| Medium | 1,080 | 26.9 | 1.12 | [0.90–1.38] | 1.10 | [0.87–1.38] |
| Low | 609 | 36.5 | 1.74 | [1.37–2.20] | 1.36 | [1.04–1.76] |
| Diet without pork meat | ||||||
| No | 2,360 | 28.8 | Ref. | Ref. | ||
| Yes | 47 | 19.2 | 0.59 | [0.28–1.22] | 0.72 | [0.33–1.59] |
| Missing | 15 | |||||
| Ever smoked | ||||||
| No | 1,034 | 26.5 | Ref. | Ref. | ||
| Yes | 1,388 | 30.3 | 1.21 | [1.01–1.45] | 0.96 | [0.79–1.17] |
| Childhood in study region | ||||||
| No | 580 | 32.2 | Ref. | Ref. | ||
| Yes | 1,816 | 27.4 | 0.79 | [0.65–0.97] | 0.85 | [0.68–1.07] |
| Missing | 26 | |||||
| Childhood on pig farm | ||||||
| No | 1,928 | 27.6 | Ref. | Ref. | ||
| Yes | 468 | 32.5 | 1.26 | [1.02–1.57] | 1.21 | [0.94–1.55] |
| Missing | 26 | |||||
| Performed jobs on farm during childhood | ||||||
| No | 1,090 | 26.9 | Ref. | - | Ref. | |
| Yes | 1,220 | 29.7 | 1.15 | [0.96–1.38] | 1.02 | [0.83–1.27] |
| Missing | 112 | |||||
| Number of pigs within 1000 m of residential address (tertiles) | ||||||
| Lowf | 807 | 32.1 | Ref. | Ref. | ||
| Intermediateg | 808 | 26.9 | 0.78 | [0.63–0.96] | 0.79 | [0.63–0.99] |
| Highh | 807 | 27.1 | 0.79 | [0.64–0.98] | 0.83 | [0.66–1.04] |
aIncluding both positive and borderline samples (anti-HEV IgG ratio > = 0.90)
bOdds Ratio
c95% Confidence Interval
dORs are adjusted for age, gender, educational level, diet without pork meat, ever smoked, childhood in study region, childhood on pig farm, jobs on farm during childhood and number of pigs within 1000 m of residential address
eAdjusted ORs and 95% CIs were calculated for cases without missing answers (N = 2,301)
fNumber of pigs within 1000 m < = 1,003
gNumber of pigs within 1000 m > 1,003 and < = 5,771
hNumber of pigs within 1000 m > 5,771