Figure 3.

Particle adhesion to inflamed mesentery endothelium as a function of combined sLe^A and aICAM sites. Comparison of dual‐targeted particle designs with single ligand densities of (A) 5,000 sites/µm² and (B) 10,000 sites/µm². Left: Diagram of particle conditions with varied amounts of sLe^A and aICAM ligand density. Middle: Quantified adherent density of firmly bound and rolling particles per representative imaging segment, n = 3 mice. Right: Velocity of rolling particles found at mesentery wall, n ≥ 50 particles from n = 3 mice. Statistical analysis of adherent density was performed using one‐way ANOVA with Fisher's LSD test between total adherent particles: (*) indicates p < .05, (**) p < .01 and two‐way ANOVA with Fishers LSD test between groups, (#) indicates p < .05, (##) p < .01 between firm groups, rolling groups n.s. Statistical analysis of rolling velocity was performed using one‐way ANOVA with Fisher's LSD test, (***) indicates p < .001. Error bars represent standard error