Fig. 5.

Motor recovery of rats subjected either to scar removal + INDP or INDP alone. a There was no significant difference among groups before intervention (p > 0.05; Kruskal–Wallis test. Mean ± SD is depicted for each group). b After intervention, rats treated with SR + INDP or INDP only showed a significant increase in motor performance when compared to PBS-immunized ones. *p < 0.01 versus PBS-I and p < 0.05 versus INDP, **p < 0.05 versus PBS-I. ANOVA for repeated measures with Bonferroni’s post hoc test. Each point represents the mean ± SD of 8 rats. c Comparison of the BBB score observed before (B) and after (P) therapeutic intervention. Rats subjected to combined SR + INDP or INDP alone presented significant improvement after intervention. *p < 0.05. Mann–Whitney U test. Mean ± SD is depicted for each group. PBS-I PBS-immunization, INDP immunization with neural derived peptide, SR + INDP scar removal + INDP