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. 2017 Jan 5;12:3. doi: 10.1186/s13023-016-0550-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Kaplan-Meier overall survival plots for LPI patients. (red vs blue lines: patients with values above vs below a cutoff, resp., horizontal axis unit : year). Panels a-c: patients grouped by plasma dibasic amino-acid levels above or below the patients’ median at diagnosis. Panel d: patients grouped by age at diagnosis greater or lesser than 1.5 years. Increased age-adjusted plasma lysine and earlier age at diagnosis were borderline predictors of poorer outcome (see text)