Table 2.
Serum concentrations of metabolites in mature mice (3-months-old) subjected to fasting and refeeding
| CON | F24 | F48 | F72 | R12 | R24 | R48 | R72 | |
|---|---|---|---|---|---|---|---|---|
| GLU | 10.28 ± 0.91 | 4.5 ± 0.54*** | 3.96 ± 1.18*** | 5.97 ± 2.67*** | 10.67 ± 1.18 | 8.29 ± 0.68* | 9.2 ± 0.95 | 9.59 ± 1.62 |
| BK | 0.16 ± 0.07 | 1.38 ± 0.4*** | 2.51 ± 0.3*** | 1.22 ± 1.01*** | 0.18 ± 0.11 | 0.1 ± 0.02 | 009 ± 0.02 | 0.11 ± 0.04 |
| TG | 1.36 ± 0.34 | 1.5 ± 0.4 | 1.57 ± 0.19 | 0.83 ± 0.19 | 2.66 ± 1.0** | 2.17 ± 1.17* | 1.88 ± 0.72 | 1.32 ± 0.52 |
| CHOL | 2.4 ± 0.86 | 2.57 ± 0.21 | 2.87 ± 0.51 | 3.44 ± 0.74* | 3.47 ± 1.02** | 3.16 ± 0.66 | 2.99 ± 0.52 | 2.42 ± 0.74 |
| NEFA | 1.39 ± 0.53 | 1.76 ± 0.49 | 2.9 ± 0.36*** | 1.42 ± 0.0.36 | 2.75 ± 0.17*** | 1.33 ± 0.41 | 1.49 ± 0.13 | 1.15 ± 0.42 |
| HDL-C | 1.82 ± 0.19 | 1.99 ± 0.18 | 2.43 ± 0.13 | 2.59 ± 0.52** | 2.72 ± 0.15** | 2.24 ± 0.4 | 2.12 ± 0.08 | 1.63 ± 0.55 |
| LDL-C | 0.2 ± 0.07 | 0.16 ± 0.02 | 0.19 ± 0.06 | 0.32 ± 0.1* | 0.64 ± 0.059*** | 0.47 ± 0.11*** | 0.65 ± 0.11*** | 0.3 ± 0.12 |
| ALB | 17.49 ± 1.17 | 17.07 ± 0.81 | 16.97 ± 0.29 | 16.13 ± 0.21* | 16.4 ± 0.53 | 15.6 ± 0.44 | 17.03 ± 0.15 | 17.04 ± 1.46 |
| TP | 50.96 ± 3.03 | 51.07 ± 1.71 | 50.1 ± 1.06 | 46.53 ± 0.9* | 46.2 ± 1.14* | 46.3 ± 1.27* | 52.43 ± 0.59 | 50.8 ± 4.21 |
All data are presented as the mean ± SEM. Statistically significant differences: * p <0.05; ** p <0.01; *** p <0.001; (One-way ANOVA) CON = control adult mice, fed ad libitum; F24, F48 and F72 = adult mice fasted for 24, 48 and 72 h, respectively; R12, R24, R48 and R72 = adult mice fasted for 72 h and subsequent fed again for 12, 24, 48 and 72 h, respectively (n = 6–8 animals in each group)