Table 3.
Select pathways in common between viral NS1-2 transfected cells and MNV infected cells
| Gene | HuNoV NS1-2 | MNV NS1-2 | MNV infected |
|---|---|---|---|
| NFkB signalling | |||
| Card11 | −1.34 | aNS | −0.88 |
| Traf1 | 2.72 | 0.09 | 3.13 |
| Ptgs2 | 2.01 | 0.19 | 2.29 |
| Nfkb2 | 1.22 | 0.13 | 1.55 |
| Relb | 1.29 | aNS | 2.49 |
| Ddx58 | 2.97 | 0.32 | 1.75 |
| Tnfaip3 | 1.00 | 0.05 | 3.26 |
| MAPK signaling | |||
| Fgf13 | −1.50 | −0.10 | −0.09 |
| Myc | 5.28 | aNS | 5.06 |
| Mef2c | −1.27 | −0.13 | −0.22 |
| Cacna1d | −3.04 | −0.36 | −0.86 |
| Gadd45g | −1.21 | −0.14 | 1.29 |
| Dusp5 | 1.93 | 0.03 | 3.35 |
| Dusp4 | 1.46 | 0.30 | 1.85 |
| Dusp2 | 1.48 | 0.11 | 2.38 |
| Nfatc1 | 1.36 | 0.12 | 0.70 |
| Ptpn5 | 1.76 | 0.42 | 1.23 |
| PI3K-Akt signaling | |||
| Pkn3 | 1.20 | 0.25 | 0.54 |
| Igf1 | −2.58 | −0.14 | −0.30 |
| Itgb5 | −1.40 | −0.03 | −0.36 |
| Lamc2 | 3.19 | 0.81 | 5.77 |
| Creb3l2 | 1.29 | 0.28 | 1.23 |
| Efna1 | 2.06 | −0.13 | −1.32 |
| Pck2 | 1.08 | 0.19 | 0.45 |
| Itga5 | 1.38 | 0.10 | 1.33 |
| Lck | 1.44 | 0.39 | 0.68 |
| TLR signaling | |||
| Ikbke | 1.24 | 0.35 | 1.13 |
| TLR8 | −2.84 | −0.20 | −2.18 |
| TLR9 | −1.04 | −0.04 | −0.57 |
| TLR4 | −0.86 | aNS | −0.47 |
| TLR7 | −0.88 | aNS | −0.28 |
| TLR13 | −1.58 | aNS | −0.68 |
| IRF9 | 2.09 | 0.15 | 1.80 |
| IRF7 | 4.51 | aNS | 2.88 |
| IRF3 | 0.19 | 0.01 | 0.26 |
| IRF1 | −0.46 | −0.1 | −0.36 |
| Apoptosis | |||
| Fas | 1.79 | 1.19 | 2.83 |
| Capn2 | 1.07 | 0.04 | 0.21 |
| IL1rap | 1.11 | 0.08 | 1.12 |
| IRAK2 | 1.19 | 0.18 | 1.97 |
| Mlkl | 1.56 | 0.32 | 0.29 |
| Tnfrsf1b | −1.76 | −0.07 | −0.70 |
| Metabolic pathways | |||
| Fut7 | −1.24 | −0.14 | −0.39 |
| Ppt1 | −1.06 | −0.14 | −0.07 |
| Pla2g2d | 1.53 | 0.18 | 0.73 |
| Khk | −1.07 | −0.23 | −0.36 |
| Ptgs1 | −1.28 | −0.07 | −0.58 |
| Pck2 | 1.08 | 0.19 | 0.45 |
| Kmo | −4.09 | −0.35 | −1.64 |
| Agpat4 | 1.46 | 0.11 | 1.34 |
| Acy1 | 1.23 | 0.15 | 0.30 |
| Il4i1 | −1.67 | −0.26 | −0.03 |
| Cth | 2.61 | 0.54 | 1.91 |
| Xdh | −2.46 | aNS | −0.90 |
| Acsbg1 | 1.76 | 0.08 | 0.63 |
| St6gal1 | −2.42 | −0.08 | −1.19 |
| Dgkg | −2.86 | −0.03 | −0.68 |
| Ugt1a7c | −1.22 | −0.02 | −0.22 |
| Ak4 | 1.06 | 0.14 | −0.27 |
| Kdsr | −1.23 | −0.15 | −0.60 |
| Acss2 | −1.24 | −0.02 | −0.32 |
| Mthfd2 | 1.19 | 0.04 | 0.59 |
| Dhrs3 | −1.90 | aNS | −1.00 |
| Dcxr | −1.02 | −0.25 | −0.36 |
| Bdh2 | 1.96 | 0.32 | 0.98 |
| Lpin3 | 1.22 | −0.06 | 0.77 |
| Gamt | −1.31 | −0.06 | −0.55 |
| Akr1b8 | 1.45 | 0.15 | 0.69 |
| Hpgds | −3.35 | −0.04 | −0.37 |
| Alox5 | −2.69 | −0.06 | −0.65 |
| Chemokine and cytokine signaling | |||
| CCL2 | 2.24 | 0.34 | 9.53 |
| CCL3 | 1.01 | 0.03 | 2.22 |
| CCL5 | 6.45 | 0.18 | bND |
| CXCL2 | 4.01 | 0.89 | 7.38 |
| CCR1 | 2.53 | 0.50 | 1.20 |
| CXCR3 | 1.09 | 0.11 | 0.09 |
| CXCR4 | −2.96 | −0.14 | −0.14 |
| CX3CR1 | −1.74 | aNS | −0.43 |
| TNF | 1.85 | 0.11 | 2.54 |
| Lif | 2.28 | 0.52 | 3.48 |
| Bcl3 | 1.25 | 0.40 | 1.54 |
| Ifnar2 | −1.24 | −0.03 | −0.55 |
| Vegfa | 1.60 | 0.09 | 0.79 |
| Il10ra | −1.91 | aNS | −1.43 |
| Csf3r | −8.20 | −0.27 | −1.00 |
Positive logFC numbers indicate upregulation, and negative numbers are downregulated genes when compared to mock-treated and cells only samples
a NS: gene detected, but FC not significant
b ND: not detected