Figure 5.

Changes in key quantities D_T and D_c for Rho-KO transcript data. Key points in time are marked on every graph. Panel A: change in D_T vs. time. The key points of 9.1 weeks and 20.3 weeks correspond to the beginning of rod degeneration and when the change in D_c is less than 0.01%, respectively. Panel B: change in D_c vs. time. The graph of D_c shows a 10% overall change whereas the change in D_T shows a 31% overall change. Panels C and D: scaled rod (solid curve) and cone (dotted curve) populations vs. time. Populations at every point were divided by the population at time 0, i.e., the first value. Plots in Panel D are zoomed in with respect to the horizontal axis. The input parameters and variables to (3) were determined from the best maximum likelihood estimator of 20,000 realistic-valued sample points using Latin Hypercube Sampling. Non-time dependent parameter values are [μ_n, μ_s, μ_c, Γ, a_n, a_s, a_c, β_n, β_s, k, d_n, d_s, γ]=[0.103, 0.0994, 0.119, 4.93, 4.909e-6, 5.24e-6, 5.12e-6, 2.50e-8, 2.29e-8, 6.37e-5, 1.91e-9, 3.69e-9, 7.54e-6].