Figure 6.

Changes in key quantities D_T and D_c for cell count data in rd1. Key points in time are marked on every graph. Panel A: change in D_T vs. time. The key points of 6.0 days and 25.1 days correspond to the beginning of rod degeneration and when the change in D_c is less than 0.01%, respectively. Panel B: change in D_c vs. time. The graph of D_c shows a 7% overall change whereas the change in D_T shows a 30% overall change. Panels C and D: scaled rod (solid curve) and cone (dotted curve) populations vs. time. Populations at every point were divided by the population at time 0. Plots in Panel D are zoomed in with respect to the horizontal axis. While the experimental data was taken for 365 days, the cone death wave takes approximately 120 days from beginning to end. The input parameters and variables to (3) were determined from the best maximum likelihood estimator of 20,000 realistic-valued sample points using Latin Hypercube Sampling. Non-time dependent parameter values are [μ_n, μ_s, μ_c, Γ, a_n, a_s, a_c, β_n, β_s, k, d_n, d_s, γ]= [0.101, 0.0990, 0.112, 4.73, 4.78e-6, 4.90e-6, 4.91e-6, 2.38e-8, 2.58e-8, 5.93e-5, 1.41e-9, 4.05e-9, 6.72e-6].