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. 2017 Jan 6;48:1. doi: 10.1186/s13567-016-0406-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histological lesions in a CT-affected animal compared to a healthy littermate and a healthy control. Vacuoles in cerebellar white matter in affected animal (A), normal white matter in littermate (B) and control (C), LFB-HE, bar = 150 µm. Hypomyelination in white matter of the thoracic spinal cord in affected animal (D), normal myelination in littermate (E) and control (F), LFB-HE, bar = 40 µm. Detection of oligodendrocytes, increased staining intensity in affected animal (G), less intense staining in littermate (H) and control (I), Olig2-IHC, bar = 40 µm.