Table 2.
Altered kinase peptides by both MEK inhibitors in more than two cell lines.
| Gene Symbol | Position | Cell Line | Direction of Change |
|---|---|---|---|
| ABL2 | 446 | A427, Calu-1 | Increase |
| AURKA | 258 | Calu-6, Calu-1, H157 | Decrease |
| CHUK | 146 | Calu-6, H157 | Decrease |
| CMPK1 | 16 | Calu-6, H157 | Decrease |
| CSNK2A2 | 159 | A427, H157 | Increase |
| JAK1 | 718 | A549, Calu-1 | Increase |
| LATS2 | 793 | A549, A427, Calu-1 | Increase |
| LATS2 | 697 | A549, A427 | Increase |
| MAP2K2 | 108 | A549, Calu-6 | Increase |
| MAP2K6 | 181 | Calu-6, A427 | Increase |
| MAST3 | 492 | A427, H157 | Increase |
| NADK2 | 76 | Calu-6, A427, Calu-1 | Increase |
| NEK2 | 143 | Calu-6, H157 | Decrease |
| NEK3 | 131 | Calu-6, H157 | Decrease |
| PGK1 | 184 | A549, A427 | Increase |
| PGK1 | 91 | A427, Calu-1 | Increase |
| PKM | 322 | A427, H157 | Increase |
| PKM | 66 | A549, A427 | Increase |
| PLK1 | 178 | A549, Calu-6, Calu-1 | Decrease |
| PLK1 | 82 | A549, H157 | Decrease |
| PRKAA1 | 40 | A427, Calu-1 | Increase |
| PRPF4B | 727 | A549, Calu-1 | Increase |
| ROCK2 | 1065 | A427, Calu-1 | Increase |
| STK38 | 118 | A427, Calu-1, H157 | Increase |
| STK38L | 119 | A427, Calu-1 | Increase |
| TK1 | 32 | Calu-6, Calu-1 | Decrease |
| TLK1 | 485 | Calu-6, Calu-1 | Increase |
| ULK1 | 140 | A549, Calu-1 | Increase |