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. 2015 Sep 16;3(3):298–327. doi: 10.3390/proteomes3030298

Figure 2.

Figure 2

Immunofluorescence microscopical localization of dystrophin isoform Dp427 in transverse cryosections from normal wild-type (wt) versus dystrophic mdx-4cv gastrocnemius muscle. Shown is the labeling of the sarcolemma in normal wt muscle using antibodies to dystrophin [71]. In stark contrast, the Dp427 isoform is almost completely absent from mdx-4cv muscle tissue. The arrow indicates a dystrophin-positive revertant fiber, which is extremely rare in the mdx-4cv mouse model of Duchenne muscular dystrophy [50].