Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A chromosomal inversion in chromosome 2 juxtaposes the 5′ end of the EML4 gene with the 3′ end of the ALK gene resulting in the fusion oncogene EML4-ALK.
Notes: The resulting chimeric protein, EML4-ALK, contains an N-terminus derived from the EML4 and a C-terminus containing the intracellular tyrosine kinase domain of ALK.
Abbreviations: EML4, echinoderm microtubule–associated protein-like 4; ALK, anaplastic lymphoma kinase.
