Table 3.
Univariate analyses of recurrence-free survival depending on treatment characteristics
| N | Estimated 1-year RFS (95% CI) | Estimated 2-year RFS (95% CI) | Estimated 5-year RFS (95% CI) | P (log-rank)* | |
|---|---|---|---|---|---|
| Margin status after initial resection | |||||
| R0 | 13 | 83.1 (47.2–95.5) | 63.3 (28.6–84.6) | 63.3 (28.6–84.6) | |
| R1/2 | 55 | 91.9 (79.8–96.9) | 91.9 (79.8–96.9) | 87.1 (73.3–94.0) | 0.053 |
| Re-excision | |||||
| No | 13 | 82.1 (44.4–95.3) | 59.8 (24.1–83.1) | 47.9 (15.5–74.7) | |
| Yes | 55 | 92.0 (80.1–96.9) | 92.0 (80.1–96.9) | 89.6 (76.7–95.6) | 0.002 |
| Margin status after first treatment round (initial resection + re-excision) | |||||
| R0 | 65 | 89.9 (78.8–95.3) | 86.0 (73.9–92.8) | 84.0 (71.3–91.4) | |
| R1 | 3 | 100 (−) | 100 (−) | (−) | – |
| Wound closure during first treatment round | |||||
| Primary closure | 35 | 80.8 (62.1–90.9) | 73.6 (53.8–85.9) | 69.7 (49.6–83.1) | |
| Non-primary closure (plastic surgical tissue transfer) | 32 | 100 (−) | 100 (−) | 96.2 (75.7–99.4) | 0.006 |
| Adjuvant radiotherapy | |||||
| No | 65 | 89.9 (78.8–95.3) | 86.0 (73.9–92.8) | 82.0 (69.0–89.9) | |
| Yes | 3 | 100 (−) | 100 (−) | 100 (−) | – |
| Distance of closest negative margin (R0 group) in cm | |||||
| ≤0.2 | 11 | 81.8 (44.7–95.1) | 71.6 (35.0–89.9) | 71.6 (35.0–89.9) | |
| 0.2–0.5 | 11 | 88.9 (43.3–98.4) | 71.1 (23.3–92.3) | 71.1 (23.3–92.3) | |
| 0.5–1.0 | 10 | 77.8 (36.5–93.9) | 77.8 (36.5–93.9) | 77.8 (36.5–93.9) | |
| >1.0 | 16 | 100 (−) | 100 (−) | 100 (−) | 0.039** |
RFS recurrence-free survival, CI confidence interval
*Log-rank test for equality of survivor functions, **Global log-rank test for the trend of survivor functions