Table 3.

Univariate and Multivariate analysis results for PFS and OS

Variable	Univariate		Multivariate Model 1		Multivariate Model 2
	PFS HR (95% CI), P-value	OS HR (95% CI), P-value	PFS HR (95% CI), P-value	OS HR (95% CI), P-value	PFS HR (95% CI), P-value	OS HR (95% CI), P-value
Sex
Male vs Female	0.49 (0.27-0.93), p = .031	0.35 (0.17-0.71), p = .005	0.64 (0.33-1.28), p = .20	0.67 (1.09-5.46), p = .33	0.56 (0.30-1.08), p = .08	0.45 (0.22-0.93), p = .03
IMDC Criteria
Favorable	ref	ref	ref	ref	ref	ref
Intermediate	2.20 (0.93-6.50), p = .08	4.13 (1.23-25.62), p = .02	2.02 (0.83-6.06), p = .13	4.02 (1.16-25.33), p = .03	1.91 (0.78-5.73), p = .17	3.42 (1.00-21.48), p = 0.05
Poor	4.46 (1.56-14.65), p = .005	10.43 (2.65-69.34), p = .0004	3.38 (1.12-11.55), p = .03	7.00 (1.68-47.83), p = .006	3.23 (1.03-11.30), p = .04	5.41 (1.20-38.24), p = .03
NLR
≤ 4 vs >4	0.51 (0.28-0.95), p = .034	0.31 (0.16-0.61), p = .001	0.68 (0.35-1.39), p = .28	0.41 (1.09-5.46), p = .03	NA	NA
Continuous (per unit change in NLR	1.05 (0.99-1.10), p = .08	1.10 (1.04-1.15), p = .002	NA	NA	1.03 (0.97-1.09), p = .30	1.08 (1.01-1.14), p = .03

CI, 95% confidence interval

HR hazard ratio, NA not applicable, NLR neutrophil to lymphocyte ratio, OS overall survival, PFS progression-free survival

Italicized p-values are less than 0.05