Table 2.
Comparison of demographic, lifestyle characteristics, serum lipid profiles and the genotype and allele frequencies of the SPTLC3 rs364585 SNP between males and females in the Han and Jing populations
| Parameter | Han | t (x 2) | P | Jing | t (x 2) | P | ||
|---|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | |||||
| No. of patients | 405 | 419 | 389 | 394 | ||||
| Age (years) | 56.88 ± 11.64 | 57.65 ± 13.10 | −0.888 | 0.375 | 57.77 ± 14.20 | 56.64 ± 12.27 | 1.129 | 0.234 |
| Height (cm) | 162.99 ± 5.56 | 151.76 ± 6.51 | 26.538 | 0.000 | 162.94 ± 6.60 | 153.29 ± 5.82c | 21.728 | 0.000 |
| Weight (kg) | 60.29 ± 8.53 | 52.54 ± 8.83 | 12.820 | 0.000 | 62.35 ± 10.02b | 55.30 ± 8.87c | 10.437 | 0.000 |
| Body mass index (kg/m2) | 22.68 ± 2.81 | 22.80 ± 3.52 | −0.560 | 0.567 | 23.42 ± 3.10c | 23.50 ± 3.30b | −0.333 | 0.740 |
| Waist circumference (cm) | 78.31 ± 8.19 | 76.63 ± 9.49 | 2.730 | 0.006 | 81.59 ± 9.83c | 79.19 ± 8.40c | 3.677 | 0.000 |
| Smoking status (n%) | ||||||||
| Non-smoker | 248 (61.2) | 418 (99.8) | 264 (67.9) | 392 (99.5) | ||||
| Smoker | 157 (38.8) | 1(0.2) | 196.00 | 0.000 | 115 (32.1)a | 2 (0.5) | 133.70 | 0.000 |
| Alcohol consumption (n%) | ||||||||
| Non- drinker | 232 (57.3) | 416 (99.3) | 292(75.1) | 389 (98.7) | ||||
| Drinker | 173 (42.7) | 3 (0.7) | 216.01 | 0.000 | 97(24.9)c | 5 (1.3) | 96.65 | 0.000 |
| Systolic blood pressure (mmHg) | 130.14 ± 16.58 | 134.58 ± 20.79 | −3.392 | 0.001 | 132.26 ± 20.77 | 132.11 ± 23.00 | 0.096 | 0.924 |
| Diastolic blood pressure (mmHg) | 81.99 ± 10.38 | 81.58 ± 10.50 | 0.554 | 0.580 | 80.68 ± 10.61 | 80.02 ± 10.00a | 0.901 | 0.368 |
| Pulse pressure (mmHg) | 48.16 ± 13.21 | 53.00 ± 16.44 | −4.651 | 0.000 | 51.59 ± 16.87b | 52.09 ± 18.71 | −0.403 | 0.687 |
| Glucose (mmol/l) | 6.58 ± 1.08 | 6.68 ± 1.04 | −1.348 | 0.178 | 6.94 ± 1.75c | 6.79 ± 1.49 | 1.307 | 0.191 |
| Total cholesterol (mmol/l) | 4.90 ± 0.83 | 5.06 ± 0.87 | −2.734 | 0.006 | 5.04 ± 0.82a | 5.11 ± 0.97 | −1.165 | 0.244 |
| Triglyceride (mmol/l) | 1.39(1.71) | 1.40(1.63) | −2.720 | 0.007 | 1.48(1.83) | 1.40(1.63) | −0.963 | 0.336 |
| HDL-C (mmol/l) | 1.74 ± 0.55 | 1.87 ± 0.48 | −2.417 | 0.000 | 1.75 ± 0.46 | 1.83 ± 0.45 | −2.417 | 0.016 |
| LDL-C (mmol/l) | 2.86 ± 0.43 | 2.89 ± 0.45 | −3.615 | 0.382 | 2.82 ± 0.37 | 2.81 ± 0.48a | 0.183 | 0.855 |
| Apo A1 (g/l) | 1.33 ± 0.21 | 1.32 ± 0.20 | 0.263 | 0.793 | 1.26 ± 0.21c | 1.30 ± 0.23 | −2.764 | 0.006 |
| ApoB (g/l) | 1.06 ± 0.23 | 1.05 ± 0.26 | 0.465 | 0.642 | 1.04 ± 0.22 | 1.03 ± 0.24 | 1.011 | 0.312 |
| ApoA1/ApoB | 1.31 ± 0.36 | 1.33 ± 0.37 | −0.697 | 0.486 | 1.26 ± 0.40 | 1.32 ± 0.37 | −2.102 | 0.036 |
| Genotype [n(%)] | ||||||||
| GG | 105(25.9) | 118(28.2) | 108(27.8) | 127(32.2) | ||||
| GA | 188(46.4) | 204(48.7) | 188(48.3) | 183(46.4) | ||||
| AA | 112(27.7) | 97(23.2) | 2.250 | 0.325 | 93(23.9) | 84(21.3) | 2.029 | 0.363 |
| Allele [n(%)] | ||||||||
| G | 398(49.1) | 440(52.6) | 404(51.9) | 437(55.5) | ||||
| A | 412(50.9) | 398(47.4) | 1.972 | 0.171 | 374(48.1) | 351(44.5) | 1.961 | 0.161 |
HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, Apo Apolipoprotein. The value of triglyceride was presented as median (interquartile range), the difference between the two groups was determined by the Wilcoxon-Mann-Whitney test. a P < 0.001, b P < 0.01 and c P < 0.05 in comparison with the same sex subgroup of the Han ethnic group