Table 2.
Univariate and multivariate analysis for blood stream infection
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | P value* | Odds ratio | 95% CI | P value* | |
| Gender (female vs. male) | 1.36 | 0.571–3.266 | 0.49 | - | - | - |
| Age (≥ 65 vs. < 65) | 1.48 | 0.591–3.681 | 0.40 | - | - | - |
| Myeloma subgroup | ||||||
| IgG vs. Non-IgG | 1.06 | 0.469–2.410 | 0.88 | - | - | - |
| IgA vs. Non-IgA | 1.12 | 0.472–2.646 | 0.80 | |||
| Immunoglobulin status | 1.18 | 0.324–4.303 | 0.80 | - | - | - |
| Severe Ig deficiencya vs. Others | ||||||
| ISS stage | ||||||
| III vs. I/II | 3.54 | 1.365–9.203 | <0.01* | 2.69 | 1.003–7.190 | 0.049 |
| ECOG PS | ||||||
| Score > 2 vs. 0–2 | 4.39 | 1.849–10.403 | <0.01* | 3.58 | 1.478–8.690 | 0.005 |
| Hb (< 10 g/dL vs. ≥ 10 g/dL) | 3.422 | 1.240–9.444 | 0.02* | - | - | - |
| Ca (> 12 mg/dL vs. < 12 mg/dL) | 3.095 | 1.013–9.454 | 0.04* | - | - | - |
| Cr (≥ 2.0 mg/dL vs. < 2.0 mg/dL) | 3.091 | 1.341–7.126 | 0.01* | - | - | - |
| ALC (< 1000/cumm vs. ≥ 1000/cumm) | 1.251 | 0.527–2.968 | 0.61 | |||
Abbreviations: IgG Immunoglobulin G, IgA Immunoglobulin A, Ig Immunoglobulin, ISS International Staging System, ECOG PS Eastern Cooperative Oncology Group Performance Status, Hb Hemoglobin, Ca Calcium; Cr Creatinine, ALC Absolute lymphocyte count
aSevere Ig deficiency: both of the non-myeloma immunoglobulin levels less than one-fourth of lower normal limit
*Significant p < 0.05 in univariate models were entered in the Cox regression multivariate model using conditional backward analysis