Table 5.

Top 20 canonical pathways identified by IPA

Ingenuity canonical pathways	-log(p-value)	p-value	Ratio	z-scorea	Number of affected molecules	Total number of moleculesb
AMPK Signaling	4.00	0.0001	0.183	−0.471	30	164
Hepatic Fibrosis/Hepatic Stellate Cell Activation	3.76	0.0002	0.180		29	161
Acetate Conversion to Acetyl-CoA	3.55	0.0003	0.800		4	5
Ovarian Cancer Signaling	3.45	0.0004	0.190		23	121
cAMP-mediated signaling	3.25	0.0006	0.162	1.257	32	197
Mitotic Roles of Polo-Like Kinase	3.08	0.0008	0.236		13	55
Glioma Signaling	3.04	0.0009	0.198	0.258	18	91
Cell Cycle Control of Chromosomal Replication	2.87	0.0013	0.308		8	26
Xenobiotic Metabolism Signaling	2.79	0.0016	0.151		33	218
LXR/RXR Activation	2.69	0.0020	0.181	0.775	19	105
Calcium Signaling	2.62	0.0024	0.161	1.698	25	155
Eumelanin Biosynthesis	2.59	0.0026	0.750		3	4
FXR/RXR Activation	2.50	0.0032	0.174		19	109
ATM Signaling	2.50	0.0032	0.214	−1.265	12	56
Ethanol Degradation IV	2.46	0.0035	0.333		6	18
LPS/IL-1 Mediated Inhibition of RXR Function	2.45	0.0035	0.151	0.378	28	185
Glioma Invasiveness Signaling	2.43	0.0037	0.211	0.577	12	57
GADD45 Signaling	2.33	0.0047	0.316		6	19
Superpathway of Cholesterol Biosynthesis	2.31	0.0049	0.280		7	25
Oxidative Ethanol Degradation III	2.26	0.0055	0.357		5	14

^az-score reflects activation, if values are positive and inactivation, if values are negative

^bTotal number of molecules present on the Bovine Gene 1.0 ST Array that are assigned to specific canonical pathways by IPA