Table 4.
Test substances | Dose (mg/kg) | % parasitaemia | % suppression | Survival time (day) |
---|---|---|---|---|
NF | 100 | 28.68 ± 6.31 | 42.11 a3,e3 | 11.33 ± 1.21a3,e3 |
200 | 28.31 ± 0.89 | 42.85 a3,e3 | 11.50 ± 1.76 a3.e3 | |
400 | 32.81 ± 4.38 | 33.77 a3,e3 | 11.00 ± 1.54 a3,e3 | |
CF | 100 | 36.25 ± 2.14 | 26.84 a3,d3.e3 | 10.50 ± 0.54 a3,e3 |
200 | 33.83 ± 3.19 | 31.71a3,d1,e3 | 10.83 ± 0.75 a3,e3 | |
400 | 29.86 ± 2.30 | 39.72 a3,b3,c1,e3 | 11.33 ± 1.03 a3,e3 | |
AF | 100 | 37.26 ± 1.84 | 24.78 a3,d3,e3 | 10.16 ± 1.47 a2,e3 |
200 | 36.10 ± 2.52 | 27.14a3,d2,e3 | 10.66 ± 1.36 a3,e3 | |
400 | 32.46 ± 2.18 | 34.47 a3,b3,c2,e3 | 11.16 ± 0.75 a3,e3 | |
Vehicle | 1 ml | 49.55 ± 2.53 | 0.00 | 7.33 ± 1.03 |
CQ | 25 | 0.00 | 100 | 27.83 ± 0.75 |
Data are expressed as mean ± SEM; n = 6; a = compared to distilled water (vehicle); b = compared to100 mg/kg; c = compared to 200; d = compared to400 mg/kg; e = compared to chloroquine 25 mg/kg
CQ chloroquine, NF n-hexane fraction of crude hydro-methanolic extract, CF chloroform fraction of crude hydro-methanolic extract, AF aqueous fraction of Crude hydro-methanolic extract
1 = p < 0.05, 2 = p < 0.01, 3 = p = <0.001