Table 3.
Changes in sitting systolic blood pressure, sitting diastolic blood pressure and low-density lipoprotein cholesterol at Week 8 from baseline
| Treatment groups | FMS/RSV vs. FMS | FMS/RSV vs. RSV | |||||
|---|---|---|---|---|---|---|---|
| FMS/RSV (N = 46) |
FMS (N = 45) |
RSV (N = 44) |
LSM difference (SE) |
P-value | LSM difference (SE) | P-value | |
| siSBP | |||||||
| Baseline | 152.52 (9.85) | 151.33 (8.99) | 154.72 (9.46) | ||||
| Week 8 | 132.05 (17.45) | 134.63 (18.70) | 150.21 (17.19) | ||||
| Change | −20.47 (15.60) | −16.70 (16.54) | −4.50 (15.50) | ||||
| P-value | <0.001a | <0.001b | 0.061a | ||||
| ANCOVA results | |||||||
| LSM (SE) | −21.89 (2.44) | −19.61 (2.66) | −6.86 (2.71) | −2.28 (3.37) | −15.03 (3.39) | ||
| (95% C.I.) | (−26.71, −17.07) | (−24.88, −14.35) | (−12.22, −1.50) | (−8.94, 4.39) | 0.500d | (−21.75, −8.31) | <0.001d |
| siDBP | |||||||
| Baseline | 89.42 (8.32) | 85.78 (9.30) | 93.08 (8.46) | ||||
| Week 8 | 80.10 (10.47) | 79.58 (8.47) | 91.73 (11.46) | ||||
| Change | −9.32 (11.23) | −6.20 (9.98) | −1.35 (9.18) | ||||
| P-value | <0.001a | 0.001a | 0.335a | ||||
| ANCOVA results | |||||||
| LSM (SE) | −10.13 (1.42) | −9.45 (1.59) | −1.18 (1.61) | −0.68 (1.98) | −8.95 (2.02) | ||
| (95% C.I.) | (−12.94, −7.31) | (−12.60, −6.30) | (−4.37, 2.01) | (−4.60, 3.25) | 0.734d | (−12.94, −4.95) | <0.001d |
| LDL-C | |||||||
| Baseline | 171.33 (36.02) | 164.09 (39.56) | 161.39 (26.71) | ||||
| Week 8 | 81.46 (27.10) | 154.40 (52.37) | 77.25 (23.33) | ||||
| Percentage change | −52.36 (12.97) | −6.52 (20.48) | −51.52 (15.80) | ||||
| P-value | <0.001b | 0.112c | <0.001c | ||||
| ANCOVA results | |||||||
| LSM (SE) | −52.74 (2.57) | −5.83 (2.77) | −50.92 (2.83) | −46.91 (3.53) | −1.82 (3.57) | ||
| (95% C.I.) | (−57.82, −47.66) | (−11.31, −0.35) | (−56.52, −45.31) | (−53.89, −39.92) | <0.001d | (−8.89, 5.24) | 0.611d |
FMS/RSV fimasartan 120 mg/rosuvastatin 20 mg treatment, FMS fimasartan 120 mg alone treatment, RSV rosuvastatin 20 mg alone treatment, LDL-C low-density lipoprotein, siSBP sitting systolic blood pressure, siDBP sitting diastolic blood pressure, SD standard deviation, LSM least square mean, SE standard error, ANCOVA analysis of covariance
Percent change from baseline was compared by apaired t-test, bone sample t-test, or cWilcoxon signed rank test
dComparison between the combination therapy and monotherapy was analyzed by ANCOVA model adjusted for baseline values, age, gender and smoking status