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. 2016 Nov 28;292(1):100–111. doi: 10.1074/jbc.M116.744482

FIGURE 2.

FIGURE 2.

Raptor deletion in mature neurons results in morphological changes in the brain and causes behavioral consequences. A, Golgi-Cox staining of 120-μm sagittal sections showed an obvious minimized soma size of cortical neurons (n = 30 per brain section). Slices were imaged by 40× objectives. B, Golgi-Cox staining of 120-μm sagittal sections showed hippocampal architecture in groups of mice (n = 6). Minimized size and sparse dendrites were observed in hippocampus of nRaKO mice (n = 6). Slices were imaged by 10× objectives. C, RotaRod examination detected motor coordination and motor learning deficits of nRaKO mice (n = 12) when compared with control (n = 15). Mice performed trials for 12 days continuously. D, Open-Field examination detected decreased locomotor activity of nRaKO mice (n = 12) when compared with control (n = 15). All data are represented as mean ± S.E. (***, p < 0.001, **, p < 0.01, *, p < 0.05). VMOVNO, number of vertical movements.