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Generation of versican conditional knock-out mice. A, LoxP sites were inserted in regions flanking versican exon 4 in C57BL6 background, targeted to create an early stop codon after the Cre recombinase induced frameshift. B, when tamoxifen was injected into these B6.Vcan-e4fl/fl mice (Cre−; control) or B6.Vcan-e4fl/fl/Rosa26-CreERT2 mice (Cre+; Vcan−/−), Cre-dependent exon 4 excision was detected, as shown by the size shift of the PCR product across exon 4 (B).
