Table 2.

Baseline independent predictors of plaque progression, inflammation progression, and high-risk plaque features

	Non-invasive imaging
	ΔWall thickness (BB-MRI)			ΔNER (IRON-MRI)			Non-calcified plaque volume (follow-up CTA)
	y = ax + β	r	P	y = ax + β	r	P	y = ax + β	r	P
Baseline ESS	−15.6x + 21.9	−0.33	0.003	−41.4x + 27.9	−0.31	0.002	−2.4x + 2.7	−0.53	<0.001
Baseline NER	26.5x − 17.3	0.38	<0.001	−59.7x + 67.0	−0.41	0.001	1.97x − 1.07	0.41	0.004
	Histopathology
	Plaque area			Lipid content			Macrophage content
	y = ax + β	r	P	y = ax + β	r	P	y = ax + β	r	P
Baseline ESS	−2.5x + 4.4	−0.50	<0.001	−17.7x + 22.7	−0.55	<0.001	−12.7x + 16.6	−0.53	<0.001
Baseline NER	1.96x + 0.61	0.23	0.04	11.3x − 1.16	0.22	0.02	10.6x − 5.3	0.32	0.003

ESS, endothelial shear stress; NER, normalized enhancement ratio; MRI, magnetic resonance imaging; CTA, computed tomography angiography.