Table 3.

Test characteristics by category of infection

Biomarker	No infection	Viral	Suspected bacterial without shock	Documented bacterial without shock	Bacterial with shock	Culture-negative septic shock	p-valuea
PCT (ng/mL)b	0.22 (0.05–1.70)	0.33 (0.07–1.45)	1.51 (0.41–4.04)	0.91 (0.10–10.80)	7.16 (2.21–42.28)	3.22 (0.36–24.93)	<0.001
CRP (mg/dL)c	1.9 (0.5–6.8)	1.4 (0.6–3.9)	5.2 (2.4–15.5)	5.0 (2.3–15.8)	18.3 (7.4–31.7)	6.2 (1.8–21.5)	<0.001
WBC (thou/μL)d	12.3 (8.1–16.0)	11.6 (8.6–15.0)	13.7 (9.5–18.6)	14.8 (10.6–18.5)	11.6 (2.8–18.8)	12.7 (8.3–20.4)	0.25
ANC (thou/μL)e	8.3 (4.1–12.0)	7.6 (5.1–12.1)	9.4 (6.3–14.7)	9.8 (5.9–14.0)	7.6 (0.4–15.4)	9.0 (4.6–13.7)	0.08
% Immaturef	0 (0–1.0)	0 (0–4.0)	0.5 (0–8.2)	0 (0–0.3)	0 (0–14.0)	2 (0–14.0)	<0.001

Data presented as median (IQR).

^ap-value calculated as test of trend across categories. For the purposes of test of trend calculation, suspected bacterial infection without shock and documented bacterial infection without shock were combined into a single category (bacterial infection without shock), and bacterial infection with shock and culture-negative septic shock were combined into a single category (shock).

^bPCT available from all 646 patients

^cCRP available from 546 patients

^dWBC available from 633 patients

^eANC available from 609 patients

^f% Immature available from 605 patients