TABLE 2.

Cellular binding partners of agnoprotein and associated functions

Virus	Agnoprotein binding partner	Binding domain within agnoprotein	Functional event	References
JCV	JCV T-Ag	1–36	Inhibition of JCV transcription and replication	Safak et al. (2001)
JCV	JCV VP1	ND	Virion assembly	Suzuki et al. (2012)
JCV	HIV-1 Tat	18–54	Inhibition of Tat-mediated HIV-1 promoter induction	Kaniowska et al. (2006)
JCV	p53	1–36	Suppression of cell cycle progression	Darbinyan et al. (2002)
JCV	Ku70	1–36	Double-strand break DNA repair	Darbinyan et al. (2004)
JCV	PP2A	18–36	Dephosphorylation of agnoprotein	Sariyer et al. (2008)
JCV	YB-1	1–36	Inhibition of YB-1-mediated transcription	Safak et al. (2002)
JCV	FEZ1	ND	Microtubule extension	Suzuki et al. (2005)
JCV	HP1a	1–18	Nuclear membrane permeability	Okada et al. (2005)
BKV	α-SNAP	1–15	Vesicle transport	Johannessen et al. (2011)
BKV	PCNA	ND	Inhibition of DNA replication	Gerits et al. (2015)
JCV	BP-3	ND	Inhibition of PB3-mediated vesicular trafficking	Suzuki et al. (2013)