Fig. 4.

Independent statistical analysis confirms increased hippocampal DG/CA3 activation in the context of impairment memory performance is observed equally in aMCI ApoE-4 carriers and aMCI ApoE-4 non-carriers. A. Sagittal view of the left medial temporal lobe. Green vertical lines identify slices through the hippocampus shown on the right. First coronal slice shows the segmentation of different hippocampal regions of interest including dentate gyrus/CA3 (DG/CA3), CA1 and subiculum (SUB). Coronal slices show statistical maps of the extent of task related activity in the left DG/CA3 from anterior to posterior. B. Patients with aMCI show increased activity in the left DG/CA3 compared to healthy control subjects during critical lure trials. C. Increased activation is observed in aMCI ApoE-4 carriers compared to controls in the left DG/CA3. D. No differences were observed between aMCI patients and healthy control subjects in other clusters of task related activation. E. ApoeE-4 carriers showed increased activation in the left CA1 compared to ApoE-4 non-carriers and reduced activation compared to controls and ApoE-4 non-carriers in the anterior left subiculum. Task related activation in the left DG/CA3/CA1 and posterior left subiculum did not differ between aMCI ApoE-4 carriers and aMCI non-carriers. Comparisons are based on independent sample t-tests. Values are means ± SEM. *p < 0.05.