Table II. Top 10 upregulated and downregulated protein in AZS in human seminal plasma. Peptide count is the total peptides found for corresponding proteins and unique peptides is the number of unique peptides out of the total peptides found. Confidence score, ANOVA p value, maximum fold change, disease class of the highest and lowest mean condition and full name of the protein are also reported in separate columns.

Accession	Peptide count	Unique peptides	Confidence score	ANOVA (p)	Max fold change	Highest mean condition	Lowest mean condition	Description
Top 10 Downregulated proteins in Asthenozoospermia in human seminal plasma samples
A0A0A0MRT2	3	2	13.3256	0.018601	3.161278	normal	astheno	WW domain-containing adapter protein with coiled-coil
K7ESQ0;K7EMH9	3	2	15.94	0.004213	3.092424	normal	astheno	Ran-binding protein 3 (Fragment)
Q9BQ16;A0A0A0MTJ2;B4DG04;E7EMP8; E7ENM6;H0YA19	8	6	40.1268	0.000845	2.755599	normal	astheno	Testican-3
Q8N0Y7	6	2	41.5525	0.000126	2.472531	normal	astheno	Probable phosphoglycerate mutase 4
Q8TF46;E9PS35	3	2	15.3761	0.0478	2.322317	normal	astheno	DIS3-like exonuclease 1
Q9NY33;E9PKK8;E9PNX5;E9PPK9;E9PQ14; G3V180;G3V1D3	3	2	14.9251	0.001695	2.228232	normal	astheno	Dipeptidyl peptidase 3
Q13163	3	2	18.7701	0.000966	2.113316	normal	astheno	Dual specificity mitogen-activated protein kinase kinase 5
P55072	5	4	31.8791	0.000223	2.080158	normal	astheno	Transitional endoplasmic reticulum ATPase
Q8IWB6;J3QLK3	6	3	29.0166	2.47E-08	2.007586	normal	astheno	Inactive serine/threonine-protein kinase TEX14
Q9NWH9;H0YLE6;H0YLW7;H0YMR6;H0YMW8; H0YNF3;H7BXE3	30	13	154.3292	0.000323	1.986234	normal	astheno	SAFB-like transcription modulator
Top 10 Upregulated proteins in Asthenozoospermia in Human seminal plasma samples
Q9BUD6	2	2	12.0373	2.08E-06	9.681792	astheno	normal	Spondin-2
Q075Z2	2	2	11.3504	0.380548	7.606171	astheno	normal	Binder of sperm protein homolog 1
I3L1D5;O15296	3	3	11.2812	0.01337	6.428859	astheno	normal	Arachidonate 15-lipoxygenase B
P30044	4	3	21.4712	8.52E-06	5.718718	astheno	normal	Peroxiredoxin-5, mitochondrial
O75503;A0A024R644	3	2	14.9273	0.253421	5.42119	astheno	normal	Ceroid-lipofuscinosis neuronal protein 5
A6NES4;A0A087WT58;C9IYW5	3	2	15.7691	0.019931	4.815401	astheno	normal	Maestro heat-like repeat-containing protein family member 2A
P62140;C9J9S3;C9JP48;E7ETD8;F5H037;F8WE71	3	2	21.701	0.002846	4.655673	astheno	normal	Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Q8WWZ1	4	4	24.2537	0.069253	3.762251	astheno	normal	Interleukin-1 family member 10
P04217;M0R009	6	4	37.2903	0.001377	3.474544	astheno	normal	Alpha-1B-glycoprotein
A4FU69;C9J1E6	3	2	24.0961	3.60E-06	3.350488	astheno	normal	EF-hand calcium-binding domain-containing protein 5