Table III. Prediction of transcription factors by UR analysis (IPA software) in HT-29 cells treated with GI50, TGI and LC50 concentrations of CA and CS for 24 hours.
| GI50 |
TGI |
LC50 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TFa | z-score | p value | Proteins | TFa | z-score | p value | Proteins | TFa | z-score | p value | Proteins | |
| CA | NFE2L2 | 2.889 | 7.72·10−11 | UGDH, TXNRD1, SQSTM1, SLC2A1, PSAT1, PGD, ME1 GCLM, GCLC, G6PD, AKR1B10 | NFE2L2 | 3.193 | 1.33·10−12 | UGDH, TXNRD1, SQSTM1, SLC2A1, PSAT1, PGD, ME1, GCLM, GCLC, G6PD, AKR1B10 | NFE2L2 | 3.028 | 1.80·10−11 | UGDH, TXNRD1, SRXN1, SQSTM1, PSAT1, PGD, ME1, HSPA9,HSP90B1, GCLM, GCLC, AKR1B10 |
| E2F1 | −2.000 | 5.83·10−8 | UGDH, TOP2A, RRM1, COPS8, PSAT1, SLC3A2, STMN1, TXNRD1 | ATF4 | 2.611 | 3.27·10−11 | WARS, SLC3A2, SARS, PSAT1, HSPA5, HSP90B1, ASNS, AARS, GARS | |||||
| XBP1 | 2.417 | 7.52·10−7 | SSR4, SSR1, SEC61B, HYOU1, HSPA5, HSP90B1 | |||||||||
| CS | NFE2L2 | 2.756 | 1.80·10−9 | TXNRD1, SQSTM1, PSMC3, PSMC1, PSMA7, HSP90AA1, GCLM, AKRQB10 | NFE2L2 | 2.799 | 4.84·10−11 | TXNRD1, SQSTM1, PSMD1, PSMC1, PSMA4, PSAT1, ME1, HSP90AA1, GCLM | ||||
a TF, Transcription Factor.