TABLE 2.
Outstanding questions in CRS microbiology research
| Question |
|---|
| What are the dynamics of the sinonasal microbiota over time in both healthy and CRS subjects? |
| Do changes in the microbiota during standard medical management of CRS predict improvement or deterioration of disease progression? |
| What is the effect of systemic antibiotics on the sinonasal microbiota in both healthy and CRS subjects? |
| What is the efficacy of standard or culture-directed antibiotics in treatment of CRS? |
| Can virus-targeted DNA and RNA (metagenome and metatranscriptome) sequencing approaches furnish a more complete picture of the role of viruses in the microbiota? |
| Can improved subclassification of variants of disease better delineate distinct microbial associations? |
| Can routine assessment of “personalized microbial genomes”a via gene-targeted or metagenomics analyses identify biomarkers of disease and inform personalized treatment approaches? |
a
See reference 197.