Figure 3.

Mucosal‐associated invariant T (MAIT) cells possess a phenotype consistent with central nervous system (CNS) infiltration and proinflammatory cytokine production. (a) CD3⁺CD4^– MAIT cells (predominantly CD8⁺, not shown) express high levels of CD161, and are predominantly effector memory (EM) (CCR7^–CD45RA^–) (b) and CCR6⁺ cells (c). This phenotype is consistent with migration to inflamed tissue, the capacity to cross the blood–brain barrier (BBB) and exert effector function, including interleukin (IL)‐17 production.