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. 2017 Jan 5;3(1):vew035. doi: 10.1093/ve/vew035

Figure 3.

Figure 3

Discovery of a flavivirus-derived EVE in An. sinensis. (A) EVE location in a generic Flavivirus genome. Positioning is based on the genome sequence of Culex flavivirus (GenBank accession no. JQ308188). C, capsid protein; E, envelope glycoprotein; M, membrane glycoprotein; NS1, non-structural glycoprotein 1; NS2A, non-structural protein 2A; NS2B, non-structural protein 2B; NS3, non-structural protein 3 (protease/helicase); NS4A, non-structural protein 4A; NS4B, non-structural protein 4B; NS5, non-structural protein 5 (RNA-dependent-RNA polymerase). (B) Phylogenetic relationships of the newly discovered An. sinensis flavivirus-derived EVEs with exogenous flaviviruses. Maximum likelihood trees were constructed based on the translated EVE sequence. Clades are color-coded according to known host specificity: green, ISFs; purple, tick-borne arboviruses; black, ‘NKV’ (vertebrate specific); blue, mosquito-borne arboviruses; red, EVEs. Scale bar indicates the number of substitutions. Node values represent SH-like branch support (only values > 0.8 are shown).