Table 1.

The trials in which the qualitative studies were nested and details of the interviews held

Trial	Trial aim	Interventions defined	Patients interviewed
1	Evaluate clinical and cost‐effectiveness of listening visits and antidepressants as treatments for post‐natal depression	Up to 8 weekly listening visits were delivered by research health visitors (RHV) in the woman's own home.	27 trial participants; 17 had been randomized to listening visits and 10 had been allocated to antidepressants.
2	Assess the clinical and cost‐effectiveness of a facilitated physical activity (FPA) intervention plus usual care, vs. usual care alone, for patients with a new episode of depression	The physical activity intervention was delivered by physical activity facilitators (PAFs) over 6–8 months. PAFs used techniques based on motivational interviewing and behavioural strategies.	33 trial participants; 19 had been randomized to facilitated physical activity (FPA) plus usual care, the rest to usual care only. 21 of the 33 were interviewed again 9 months later.
3	Examine the clinical and cost‐effectiveness of CBT plus usual care, vs. usual care alone, for patients with treatment resistant depression	Face‐to‐Face CBT was delivered by CBT therapists. Patients were allowed up to 18 one‐hour sessions, in the patient's own GP surgery or nearby NHS or University premises.	40 trial participants interviewed; 26 had been randomized to CBT plus usual care and 14 to usual care alone.
4	Investigate the clinical and cost‐effectiveness of online CBT for patients with a new episode of depression	Online CBT was delivered by psychologists. Patients were offered up to 10 sessions.	24 patients interviewed prior to receiving online CBT. 20 of these participants were interviewed again having completed (n = 15) or withdrawn from treatment (n = 5)