Table 5.
Gene ontology analysis: top pathways
| Canonical pathways | z‐score | Molecules |
|---|---|---|
| Cell cycle: G2/M DNA damage checkpoint regulation | 1.134 | GADD45A, TOP2A, ATR, AURKA, CDK1, SKP2, CCNB1 |
| HGF signaling | 1 | MET, FOS, IL6, ELK3, PRKCB |
| PPAR signaling | 1 | IL33, FOS, IL36G, IL1A |
| LXR/RXR activation | 0.447 | IL33, IL36G, IL1A, SERPINA1, IL6 |
| Activation of IRF by cytosolic pattern recognition receptors | −0.447 | IFIH1, IL10, DDX58, IL6, STAT1, ISG15 |
| PDGF signaling | −0.447 | FOS, CAV1, EIF2AK2, STAT1, PRKCB |
| IL‐6 signaling | −0.447 | IL33, FOS, IL36G, IL1A, IL6 |
| NF‐κB signaling | −0.447 | IL33, IL36G, IL1A, EIF2AK2, PRKCB |
| ERK/MAPK signaling | −0.447 | FOS, STAT1, ELK3, DUSP2, PRKCB |
| Cholecystokinin/gastrin‐mediated signaling | −0.816 | IL33, FOS, IL36G, IL1A, MEF2C, PRKCB |
| Toll‐like receptor signaling | −1 | IL33, FOS, IL36G, IL1A, EIF2AK2 |
| Growth hormone signaling | −1 | FOS, IGFBP3, STAT1, PRKCB |
| JAK/stat signaling | −1 | STAT4, FOS, IL6, STAT1 |
| TREM1 signaling | −1 | IL10, IL6, FCGR2B, CSF2 |
| Tec kinase signaling | −1 | STAT4, FOS, STAT1, PRKCB |
| Production of nitric oxide and reactive oxygen species in macrophages | −1 | FOS, SERPINA1, STAT1, PRKCB |
| Colorectal cancer metastasis signaling | −1 | FOS, IL6, STAT1, MMP19 |
| Role of CHK proteins in cell cycle checkpoint control | −1.342 | PCNA, RFC4, ATR, CDK1, CDC25A, RFC3, NBN |
| HMGB1 signaling | −1.342 | FOS, IL1A, IL6, SERPINE1, CSF2, PLAT |
| p38 MAPK signaling | −1.342 | IL33, IL36G, IL1A, MEF2C, STAT1 |
| Aryl hydrocarbon receptor signaling | −1.342 | CCNA2, FOS, IL1A, ATR, IL6 |
| Acute phase response signaling | −1.414 | IL33, FOS, IL36G, IL1A, FN1, SERPINA1, IL6, SERPINE1 |
| VDR/RXR activation | −2 | GADD45A, IGFBP3, CYP27B1, CSF2, PRKCB |
| UVA‐induced MAPK signaling | −2 | FOS, ZC3HAV1, PARP12, STAT1 |
| Role of NFAT in regulation of the immune response | −2 | FOS, MEF2C, FCGR2B, RCAN2 |
| Interferon signaling | −2.236 | IFIT3, IFIT1, OAS1, MX1, STAT1 |