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. 2016 Jul 8;8(1):44–55. doi: 10.1111/jdi.12540

Figure 1.

Figure 1

Chronic mild hyperglycemia incubation reversed diabetes in single high‐dose streptozotocin (STZ)‐treated rats. Eight‐week‐old male SD rats were treated with a single high dose of STZ (65 mg/kg), and 48 h post‐STZ injection newly diabetic rats (blood glucose >25 mmol/L) were randomly treated with: no treatment (HG; n = 6), daily exogenous long‐acting human insulin analog injection that restored normoglycemia (NG; blood glucose <8 mmol/L, n = 8), or maintained mild hyperglycemia (mHG; 15 mmol/L < blood glucose < 18 mmol/L, n = 15). Six normal rats were used as normal controls. Insulin withdrawal was executed within 30 days in the mHG group and at day 80 in the NG group. (a) Random blood glucose levels were monitored for 90 days. (b) Fasting serum insulin levels were detected at the end of observation. (c,d) Blood glucose levels and insulin levels during intraperitoneal glucose tolerance tests at the end of observation. The results are presented as the mean ± standard deviation. **P < 0.01. NS, not significant.