TABLE 1.
Quantitation of histologic injury, caspase-3 activation, and viral load in virus-infected myocardium over time postinfectiona
| Day postinfection | Myocardial injury score | Caspase-3 activation score | Viral titer in Tissue (log10 PFU/ml) |
|---|---|---|---|
| 3 | 0.0 ± 0.0 | 0.0 ± 0.0 | 4.4 ± 0.1 |
| 4 | 0.8 ± 0.5 | 0.5 ± 0.0 | 5.6 ± 0.4 |
| 5 | 1.0 ± 0.5 | 1.0 ± 0.0 | 7.5 ± 0.1 |
| 6 | 2.6 ± 0.3 | 2.2 ± 0.2 | 7.6 ± 0.5 |
| 7 | 3.3 ± 0.3 | 3.2 ± 0.2 | ND |
a
Consecutive 4-μm-thick sections of hearts from reovirus-infected mice on days 3 to 7 postinfection (n = 26) were scored quantitatively for histologic injury (0 to 4) and caspase-3 activation (0 to 4). Myocardial viral titers were also determined on days 3 to 6 postinfection. Mean scores (± standard errors of the means) for histologic injury, caspase-3 activation, and viral titers are reported for each day (derived from 2 to 6 mice per day). ND, not done.