TABLE 1.
Clinical, virologic, and immunologic characteristics of patients
| Patient no. | Sample dated | Plasma HIV-1 load (no. of copies/ml) | Lambda value (λ)a | CD4+ count, cells/mm3 | Antiretroviral treatmentb |
|---|---|---|---|---|---|
| 9 | 3/96 | 90,500 | 0.90 | 11 | 3TC, d4T, SQV |
| 6/96 | 2,300,000 | 0.36 | 37 | d4T, IDV | |
| 1/97 | 320,000 | 1.00 | 35 | 3TC, d4T, IDV | |
| 28 | 1/96 | 19,000 | 0.52 | 670 | None |
| 4/96 | 34,000 | 0.28 | NAc | None | |
| 1/97 | 10,500 | 1.00 | 274 | AZT | |
| 17 | 6/96 | 195,000 | 1.00 | 23 | 3TC, d4T, IDV |
| 7/96 | 200,000 | 0.90 | 11 | 3TC, d4T, IDV | |
| 11/96 | 72,000 | 1.00 | 21 | 3TC, ddC, IDV |
a
λ is a nonlinear variable representing the proportion of strains using CCR5: λ = 1 represents an isolate in which all strains prefer CCR5 whereas λ = 0 indicates that all prefer CXCR4 (16).
b
SQV, saquinavir, IDV, indinavir; 3TC, lamivudine; d4T, stavudine; AZT, zidovudine; DDC, dideoxycytosine.
c
NA, not available.
d
Shown as month/year (1996 or 1997).