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Engineered mutations in NS4B's NBM. (A) Consensus sequences for all NBM-containing proteins, all HCV isolates, and HCV genotype 1b. X, any amino acid. (B) Single-amino-acid point mutations (gray) were engineered into the NBM of NS4B at the indicated positions. (C) Effect on poliovirus replication of mutations engineered at the same positions in the poliovirus 2C protein's NBM (22, 31). N.D., not done.
