FIG. 1.

The mTOR signaling pathway. The phosphorylation characteristics of mTOR downstream effectors and the status of the eIF4F complex when mTOR is either active or inactive are shown. The points at which hypoxia and rapamycin inhibit mTOR are indicated. S6K, p70S6 kinase; Mnk1, mitogen-activated protein kinase signal-integrating kinase 1.