FIG. 3.

Myristic acid analogs inhibit LCMV multiplication. (A) Treatment of LCMV-infected cells with 2-OHM eliminates virus production. BHK-21 cells were infected with LCMV at the indicated MOI in the presence (+) or absence (−) of 2-OHM (100 μM). Forty-eight hours later, SP were harvested and viral titers were determined by plaque assay. Virus production is represented as a percentage of the infectivity observed in LCMV-infected untreated controls (100%). (B) Treatment with 2-OHM does not affect LCMV transcription and replication. RNA isolated from treated and untreated LCMV-infected cells was analyzed by Northern blot using a ³²P-labeled NP DNA probe.