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(A) In vitro biochemical assay for HDAC1, HDAC2 or HDAC3 inhibition by ACY-957 (left panel) and ACY-1035 (right panel). Mean ± SD, n = 3. (B) MV-4-11, Kasumi-1 or HL-60 cells were treated with the indicated doses of compounds for 24 hours and immunoblotting performed for acetylated H2BK5, acetylated H3K56 and total H4. A dose-dependent induction of histone acetylation by ACY-957 or ACY-1035 was observed.
